Efficacy and Safety of Transcranial Magnetic Stimulation in Treatment of Alzheimer's Disease

Summary

This study is grounded in the regulatory mechanisms of the glymphatic system and applies repetitive transcranial magnetic stimulation (rTMS) to the treatment of Alzheimer's disease (AD). The clinical efficacy and safety of rTMS will be systematically evaluated. Furthermore, transcranial magnetic stimulation-evoked potentials (TMS-EEG) and functional near-infrared spectroscopy (fNIRS) will be employed to investigate, from the perspectives of synaptic plasticity and neurovascular coupling, the mec

Eligibility

Inclusion Criteria: * Meets the 2018 NIA-AA diagnostic criteria for Alzheimer's disease (AD) * Meets DSM-5 diagnostic criteria * Mild to moderate disease severity (CDR Global Score 1 to 2) * Evidence of AD pathology: positive amyloid PET OR positive cerebrospinal fluid (CSF) AD biomarkers OR positi

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