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Depression Neuromodulation trials

SAINT in Postpartum Depression (PPD)

RecruitingNCT07210255Phase: NAStarted 2025-11-01

Summary

This study is a large, multi-site clinical trial testing whether Stanford Accelerated Intelligent Neuromodulation Therapy (SAINT), a fast-acting form of repetitive transcranial magnetic stimulation (rTMS), can more effectively reduce symptoms of postpartum depression (PPD) compared to a sham treatment. It will enroll 192 women within 12 months postpartum who are experiencing depression that has not improved with standard care, and will track their progress for up to 12 months. The trial's main

Eligibility

Sex
FEMALE
Min Age
18 Years
Max Age
45 Years

Inclusion Criteria: 1. Reproductive Women ages 18-45 at the time of consent. 2. Diagnosis of non-psychotic Major Depressive Episode (MDE) with peripartum onset as assessed through the Quick Structured Clinical Interview for DSM-5. 3. 0-12 months postpartum. Participants must be 0-12 months postpart

Locations

UMass Chan Medical School
Worcester, Massachusetts, United States
Icahn School of Medicine at Mount Sinai
New York, New York, United States
The Medical University of South Carolina (MUSC)
Charleston, South Carolina, United States
University of Texas at Austin, Dell Medical School, Health Discovery Building
Austin, Texas, United States

Interested in participating? View the full study details on ClinicalTrials.gov:

View on ClinicalTrials.gov →