Combining rTMS & Aerobic Exercise to Treat Depression and Improve Post-Stroke Walking

Summary

Investigators primary aim is to carry out a two-site, randomized, double-blind, sham-controlled, phase II trial to systematically examine the potential for aerobic exercise (AEx) to enhance the anti-depressant benefits of rTMS in individuals with post-stroke depression (PSD). Investigators propose to determine the efficacy of combining two known anti-depressant treatments shown to be effective in non-stroke depression, aerobic exercise (AEx) and repetitive transcranial magnetic stimulation (rTM

Eligibility

Inclusion Criteria: * age 21-70 * stroke within the past 12 to 60 months * screen positive for probable major depressive disorder (PHQ-9 \> 10) and HAM-D17 ≥ 14 * residual paresis in the lower extremity (Fugl-Meyer LE motor score \<34) * ability to walk without assistance and without an AFO at spee

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