Deep Brain Stimulation Surgery for the Treatment of Refractory Obsessive-Compulsive Disorder

Summary

This study will include two parts. The first part will include two patients in a non-blinded, non-randomized, open trial. They will undergo Deep Bran Stimulation (DBS) for OCD (targeting the amSTN), as clinically accepted and approved in Israel (by the MOH) and in other countries in Europe and the US. The second part will include eight patients. This part will be an interventional, randomized, double-blinded clinical trial (patient and psychiatrist; the neurosurgeon will activate stimulation dur

Eligibility

Inclusion Criteria: * Patients with a diagnosis of obsessive-compulsive disorder according to DSM 5 criteria, diagnosed by three independent psychiatrists not routinely involved with the patients' treatment. * Severe OCD assessed by the Yale-Brown Obsessive-Compulsive Scale (YBOCS) with a score of

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