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Cardiac Autonomic and Anxiety Regulation Via Closed-loop nEurofeedback in Recurrent Pregnancy Loss

RecruitingNCT07325370Phase: NAStarted 2025-12-29

Summary

The goal of this clinical trial is to learn whether right dorsolateral prefrontal cortex (right DLPFC)-targeted fNIRS-BCI online closed-loop neurofeedback, delivered with slow-wave acoustic cueing, can reduce anxiety symptoms and improve cardiac autonomic regulation in women with recurrent pregnancy loss (RPL) and comorbid anxiety (women aged 18-45 years, right-handed, currently not pregnant or in a missed miscarriage state). The main questions it aims to answer are: Does real neurofeedback in

Eligibility

Sex
FEMALE
Min Age
18 Years
Max Age
45 Years

Inclusion Criteria: * (i) Women aged 18-45 years, right-handed; * (ii) Diagnosis of recurrent pregnancy loss (RPL), defined as ≥2 consecutive spontaneous pregnancy losses occurring before 28 weeks of gestation; * (iii) Not currently pregnant, or currently in a missed miscarriage state; * (iv) Meet

Locations

The Second Affiliated Hospital of Shenyang Medical College
Shenyang, Liaoning, China
Central Hospital Affiliated to Shenyang Medical College
Shenyang, Liaoning, China

Interested in participating? View the full study details on ClinicalTrials.gov:

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